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Research papers to download

  • Schultz F, Hasan A, Alvarez-Laviada A, Miragoli, M, Bhogal N, Wells S, Poulet C, Chambers, J, Williamson C, Gorelik J. The protective effect of ursodeoxycholic acid in an in vitro model of the human fetal heart occurs via targeting cardiac fibroblasts. Progr Biophys Molec Biol 2016; http://dx.doi.org/10.1016/j.pbiomolbio.2016.01.003
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  • Abu-Hayyeh S, Ovadia C, Lieu T, Jensen DD, Chambers J, Dixon PH, Lovgren-Sandblom A, Bolier R, Tolenaars D, Kremer AE, Syngelaki A, Noori M, Williams D, Marin JJG, Monte MJ, Nicolaides KH, Beuers U, Oude-Elferink R, Seed PT, Chappell L, Marschall H-U, Bunnett NW, Williamson C Prognostic and mechanistic potential of progesterone sulfates in intrahepatic cholestasis of pregnancy and pruritus gravidarum. Hepatology 2015; doi: 10.1002/hep.28265
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  • Geenes V, Chambers J, Khurana R, Wikström Shemer E, Sia W, Mandair D, Elias E, Marschall H-U, Hague W, Williamson C (2015) Rifampicin in the treatment of severe intrahepatic cholestasis of pregnancy. European Journal of Obstetrics & Gynecology and Reproductive Biology, Volume 189. pages 59–63
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  • Geenes V, Chappell LC, Seed PT, Steer PJ, Knight, M, Williamson C Association of severe intrahepatic cholestasis of pregnancy with adverse pregnancy outcomes: a prospective population-based case-control study. Hepatology 2014; First published online 26 February 2014; DOI: 10.1002/hep.26617
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  • Chappell LC, Gurung V, Seed PT, Chambers J, Williamson C, Thornton JG. Ursodeoxycholic acid versus placebo, and early term delivery versus expectant management, in women with intrahepatic cholestasis of pregnancy: semifactorial randomised clinical trial. BMJ 2012; 344 doi: 10.1136/bmj.e3799
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  • Victoria Geenes and Catherine Williamson (2009) Intrahepatic cholestasis of pregnancy. World Journal of Gastroenterology, Volume 15, Issue 17, Pages 2049–2066.
    This is the most recent review of our current state of knowledge of ICP.
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  • Anna Glantz, Hanns-Ulrich Marschall and Lars-Åke Mattsson (2004) Intrahepatic cholestasis of pregnancy: Relationships between bile acid levels and fetal complication rates. Hepatology, Volume 40, Issue 2, Pages 467–474. (DoI: 10.1002/hep.20336)
    This paper reports more extensively the connection between high levels of bile acids and potential risk to the baby.
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  • Andreas E. Kremer et al. (2010) Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology, Volume 139, Pages 1008–1018.
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  • E Wikström Shemer et al. (2013) Intrahepatic cholestasis of pregnancy and associated adverse pregnancy and fetal outcomes: a 12-year population-based cohort study. British Journal of Obstetrics and Gynaecology, DOI: 10.1111/1471-0528.12174.
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